布莱顿和苏塞克斯医学院招收医学物理学博士

About the Project

The overall goal of this PhD thesis is the development and implementation of metabolic imaging techniques, includingarterial spin labelling (ASL) perfusion MRI1 and quantitative BOLD MRI2 , for a comprehensive assessment of oxygen metabolism in the healthy brain at baseline. This is a methodology driven thesis that will provide the tools for future basic neuroscience and/or clinical applications such as mitochondria diseases and stroke. The candidate will work on proving the feasibility of multi-method imaging for providing absolute measurement of cerebral oxygen metabolism at baseline and during modulated breathing conditions, potentially including visual and/or motor activation.

The PhD student will be involved in implementing, testing, and optimizing the sequences, including writing the relevant software for image processing and analyses.

Successful completion of the thesis will ensure that the candidate has gained:

(1) Knowledge of the fundamental principles of brain function and anatomy;

(2) Knowledge of the basic mathematical and physics of neuroimaging;

(3) Ability to acquire brain images using two different hardware systems;

(4) Ability to develop software for multi-modal image processing.

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